Epstein -Barr Virus (EBV), a member of the Herpes Virus family is often overlooked compared to its cousins HSV-1, HSV-2, VZV and CMV. As an Infectious Disease physician I suspect that this is in part due a taint that goes back to the days of patients complaining that they had "Chronic EBV" or chronic fatigue due to EBV (neither of which was true). Additionally, the currently available anti-virals Acyclovir, Valacyclovir, Ganciclovir and Valganciclovir have not demonstrated clinical improvement in patients with EBV infection. EBV infects approximately 90 % of people during their lifetime. Approximately 30-40% of people infected will develop acute infectious mononucleosis (IM).The annual rate of IM in college students and military recruits is 1-5%. This is characterized by high fevers, lymphadenopathy, exudative pharyngitis, transaminitis, and splenomegaly. While acute IM from EBV is not associated with significant mortality it is associated with a significant morbidity.